ABSTRACT
Background: Magnetic resonance enterography [MRE] has become the modality of choice in assessment of patients with Crohn's disease [CD]
We aimed to present our experience on 300 patients with CD who underwent MRE during the first 30 months after setting up MRE for the first time in a referral center in Iran
Methods: Patients with a definite diagnosis of CD based on either ileocolonoscopy or histopathological studies were included in the final report and categorized into four phenotypes of inactive, active, stricturing, and penetrating disease
Results: This was a case series study on 300 patients with known CD out of 594 referred subjects. The most prevalent phenotype was inactive observed in 162 [54.0%] patients followed by stricturing in 44 [14.7%], active in 40 [13.3%], penetrating in 27[9%], and active on chronic in 27 [9%] cases. The number of referred patients increased from 51 cases in the first 6 months to 165 in the last 6 months
Conclusion: This study presents the first report on the application of MRE in Iran as superb modality for management of CD. The growing number of referred patients indicates that MRE has been successful in addressing the most critical concerns of clinicians on determining the dominant disease phenotype
ABSTRACT
Methicillin resistant staphylococcus aureus [MRSA] is a frequent cause of infections in children. The purpose of this study was to determine the frequency of nasal colonization of S. aureus in children and detection of inducible clindamycin resistance [ICR] by disk approximation test [D-test]. This was a cross-sectional study conducted in Hamedan from 2007 to 2008. 520 nasal swabs were obtained from children under 12 years of age at the time of admission and 287 swabs at the time of discharge. Antibiogram was performed by method of disk diffusion for oxacillin, erythromycin, clindamycin, cefazolin and vancomycin as well as D-test. Chi-square test was applied for statistical analysis. Out of 520 patients, 118 [22.3%] were colonized with S. aureus as community-acquired [CA-S. aureus]. Of 287 patients, 64 [22.3%] were colonized with isolates of S. aureus at discharge time. Of these 64 patients, 32 cases were colonized with hospital acquired [HA-S. aureus] isolates after admission. Only one CA-MRSA isolate was resistant to clindamycin, 5% of 118 CA-S. aureus isolates and 6.3% of HA-S. aureus isolates had inducible clindamycin resistance [D-test]. Also 37.5% of CA-MRSA isolates at the time of admission and 22.2% of HA-MRSA isolates at discharge had positive D-test. We emphasize that D-test should be used routinely and clindamycin should not be used in patients with infections caused by inducible resistant S. aureus